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133 Further, in vitro studies using human cell lines have shown that acetaminophen can cause an immediate, reversible, dose-dependent loss of oxygen uptake followed by a slow, irreversible, dose-independent death and have suggested mechanisms by which acetaminophen may cause toxicity in tissues other than the liver

While RSL3 promotes ferroptosis via inhibition of GPX4, it also appears to enhance tumor cell DNA damage

doi: 10.1007/s00213-017-4730-6 109 ShimonIRudmanYManisterskiYGorshteinAMasriHDuskin-BitanH

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