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The carnitine shuttle becomes effectively useless if the downstream electron transport chain lacks the oxygen required to finalize ATP production, creating a compounding energy crisis that leaves patients feeling physically paralyzed by exhaustion

In 1996, a family with recurrent unexplained infant deaths were investigated with all available pathology and genetic methods possible at that time

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The authors concluded that RB directly interacts with Drp1 at mitochondria and forms a complex that enhances the formation of necrosome by binding to RIPK3 [215]