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Secondary outcomes of interest included change in sleep apnea-specific hypoxic burden, cardiovascular risk (CV) factors (changes in body weight, systolic blood pressure, and inflammation), and changes in patient-reported sleep troubles

5-amino-1mq is commonly available in oral capsule form and appears to have reasonable oral bioavailability based on rat pharmacokinetic studies

Clinical trials demonstrated that patients who followed gradual escalation experienced significantly fewer gastrointestinal side effects compared to those on faster schedules

Increase fiber gradually, and pair it with fluids to avoid digestive discomfort

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