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This work was supported by the China Postdoctoral Science Foundation (Grant #2022YFC3602300 and Grant #2024T171044), the Shenyang Public Health R&D Special Projects in 2022 (Project Grant #22-321-33-10), and the Scientific Research Fund Project of the Department of Education of Liaoning Province (Grant #JCZR2020005)

Molecular durability is achieved through peptide engineering strategies that (i) confer resistance to DPP-4 cleavage, typically via N-terminal modification, and/or (ii) extend systemic exposure through fatty-acid acylation, which enhances albumin binding and slows renal clearance, thereby prolonging receptor activation [18]

The primary outcome was a composite of major adverse limb events, defined as peripheral artery disease (PAD), critical limb ischaemia, percutaneous transluminal angioplasty or peripheral bypass for PAD, and amputation

The study was supported (funded) by NIH/NIDDK DK129474 (Vaughan, PI)

Pregnant patients exposed to Zepbound and healthcare providers are encouraged to contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979)