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GLP-1s are contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome Type 2

All above is consistent with anti-inflammatory effect of GIPR/GLP1R agonism, which plays a role in improving atherosclerosis lesion severity

Unlike BPC-157, which has been in the Canadian market for years and is relatively difficult to fake because the market norms are well-established, retatrutide is newer

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