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Animal studies have suggested that metformin enhances the weight loss efficacy of GLP-1 RAs by stimulating GLP-1 receptor expression and augmenting insulin-mediated signaling pathways

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Clinical trials of GLP1 and GIP/GLP1 therapies show meaningful total weight loss, but a slice of that loss comes from fatfree mass (which includes muscle, bone and body water) (Jendle et al., 2022)

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