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The majority of circulating biologically active GLP-1 in man is the GLP-1 (7-36) amide form, with lesser amounts of the bioactive GLP-1 (7-37) form also detectable (Orskov et al., 1994)

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Three-carbon disulfide re-bridging chemistry, combined with structure-guided PEGylation originally developed for fibroblast growth factor 2, has now been applied to GLP-1 scaffolds

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