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Current Food and Drug Administration (FDA)Approved and Investigational GLP-1RAs Exenatide, the first FDA-approved GLP-1RA (2005), showed potential for significant weight loss, though more evidence is needed for use in treating uncomplicated obesity [1619]

Compared to individuals without diabetes, patients with diabetes present a higher atheroma volume, a smaller arterial lumen, more rapid progression of atherosclerosis, more macrophage accumulation, and a higher incidence of thrombus [15, 16]

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One mouse was found dead in vehicle group

Eli Lilly's orforglipron and Pfizer's daily acting danuglipron represent the latest oral non-peptide GLP-1 agonists, striving for parity in efficacy with the injectables, with the advantage of being more readily manufactured