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Data synthesis and analysis The means and standard deviations of changes in the outcomes were converted from milligrams per decilitre (mg/dL) to millimoles per litre (mmol/L), and the variance was calculated using a previously developed program.32 We applied the following formula to studies missing standard deviation data.33 If only P values were reported, we used the METAEFF command program in Stata version 17 (Stata Corp LLC) software to calculate the mean difference and 95% confidence interval from the available data.34 We performed network meta-analyses of randomised controlled trials with Stata and used the Stata command MVMETA35 to perform multivariate network meta-analyses in the frequentist framework.36 The relative effects were measured as mean differences for continuous outcomes, including HbA 1c concentrations, fasting blood glucose concentrations, body weight, etc, and odds ratios for binary outcomes, such as adverse events

GLP-1 medications are meant for long-term use

The case for cost savings to the public purse is also murky

Each participant was assessed by waist circumference measurements

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