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Clinical Evidence on Retatrutide Efficacy Phase 3 clinical trials (REFRAME and REFRAME-2) evaluated retatrutide in individuals with type 2 diabetes and obesity over 68 weeks

Higher doses produce increased incidence and severity of gastrointestinal symptoms, which explains why clinical protocols use gradual dose escalation starting at 0.25 mg weekly and incrementally increasing every 4 weeks

In real-world settings, most patients naturally reduce portion sizes by 4050% within the first month of consistent use

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After 8 weeks of treatment, tirzepatide significantly reduced fasting plasma glucose levels, HbA1c levels (a measure of long-term blood sugar control), and body weight compared to the placebo